Iconic ‘Grey’s Anatomy’ Guest Stars Over the Years: Demi Lovato, Millie Bobby Brown, and More

Over its many seasons, *Grey’s Anatomy* has become famous not only for its gripping medical dramas but also for featuring a star-studded list of guest appearances. From pop icons to rising stars, the long-running medical series has welcomed several notable celebrities who’ve left a lasting impression. Among them are Demi Lovato, Millie Bobby Brown, and many more.

**Millie Bobby Brown** appeared in Season 11, Episode 15, playing Ruby, a young girl who must save her mother’s life over the phone with the guidance of Dr. Owen Hunt. Before skyrocketing to fame with *Stranger Things*, Brown showcased her emotional range in this intense episode, making a memorable mark on the show.

**Demi Lovato** guest-starred in Season 6, Episode 22, playing Hayley May, a teenager wrongly diagnosed with schizophrenia. Lovato's character undergoes surgery to correct the issue, highlighting the medical brilliance of *Grey’s Anatomy* doctors while showcasing Lovato's acting chops in a moving and dramatic role.

Other unforgettable guest stars include **Sarah Paulson**, who played the young version of Dr. Ellis Grey, and **Mandy Moore**, who appeared as patient Mary Portman. Each brought their unique talents to the series, creating memorable moments that fans still talk about today.

These high-profile guest stars have not only contributed to some of the series’ most iconic episodes but also added a layer of excitement and buzz to *Grey’s Anatomy*, proving the show's broad appeal in Hollywood.